Nanoapproaches for Cystic Fibrosis – Design, Characterization and InVitro Evaluation by Saptadeep Nandi & team

The following are the research works carried out by various researches Scholars that strongly support to carry out the present dissertation work.




 Literature review :

AnayatollahSalimi 1, et al., (2022) developed and characterized the Self-Emulsifying Drug Delivery System (SEDDS), to Improve the Oral bioavailability of poorly water soluble drug of Carvedilol. The percentage of drug release after 24 hours (R24) for Poloxamer and hydroxypropyl methylcellulose formulations were 61.24-70.61% and to 74.26-91.11%, individually. In permeation studies a significant and direct correlation existed between P4 and surfactant/co-surfactant ratio. The system (self-emulsifying drug delivery system) showed drug permeability through the rat intestine 2.76 times more, compared with the control.

Hyma.P et al., (2022) formulated and characterized the novel self-micro emulsifying drug delivery system of glimepiride to enhance the solubility and oral bioavailability of poorly water-soluble drug. SMEDDS are the isotropic mixture of oil, surfactant and co-surfactant, incorporated with drug. The emulsification takes place in aqueous media in GI, with gastro intestinal motility. Pseudo ternary titrations were done using surfactants/co-surfactants and oil in different ratios with water. The self-emulsifying region was identified by constructing pseudo ternary diagram. Finally concluded that various tests proved to be satisfying the required parameters for effective drug dissolution and diffusion. The rate of dissolution of glimepiride increased in SMEDDS formulation.

M. Sunitha Reddy et al., (2021) prepared and evaluated of Solid Self-Emulsifying Drug Delivery Systems of Efavirenz, poorly water-soluble drugs. To enhance the dissolution rate and bioavailability of poorly water-soluble drug, one of the promising techniques is Self‐Micro Emulsifying Drug Delivery Systems (SMEDDS). Results proved that prepared solid SEDDS have good flow properties and improved drug solubility and dissolution profiles (99.95%) when compared to pure efavirenzTo improve the oral bioavailability of hydrophobic/lipophilic drugs SNEDDS is one of most promising approach to overcome formulation difficulties towards dissolution/solubility. In this study SNEDDS of drug could be effectively developed and measured for its invitro and in vivo performance. In terms of droplet size, poly dispersibility index, dissolution and diffusion studies, S9 formulation showed promising result. Zeta potential of S9 formulation was -51.6 mV which indicates good stability and high degree of repulsion between adjacent, similarly charged globules in dispersion. Finally concluded that SNEDDS formation from captex-200, tween 80, PEG-200, Smix (surfactant co-surfactant ratio) (4:1) and Smix: oil ratio (1:9) is promising approach to improve the solubility, dissolution rate of drug.

 Potential advantages of SNEDDS include :

1.Nasal bioavailability increased with reduced dose size.

 2. Increases the drug absorption.

 3. Having specific absorption window in nasal route.

 4. Protects the drug from the contamination.

 5. Reduces the variability including other effects.

 6. Protects sensitive drug substances.

 7. High drug loads.


STUDY RESULTS:

S.NO

Parameter

Formulation

1.    

Particle Size Distribution

85.6 d.nm

2.    

Zeta Potential

-51.6mV

3.    

Polydispersity Index

0.931

4.    

Scanning Electron Microscopy

101.3 nm

5.    

Drug content

99.23±0.45%

6.    

Emulsification time

Spontaneous, within 56 sec

7.    

Thermodynamically

Stable

8.    

% Transmittance

99.98 %

9.    

In-vitro studies

The formulation shown 97.72% cumulative release higher than other selected formulations   

(S4-S8)

10. 

Stability studies

The self-nanoemulsion stored in temperature range of 400C- 75% R.H shown better stability up to 1 months

 

CONCLUSION

To improve the oral bioavailability of hydrophobic/lipophilic drugs SNEDDS is one of most promising approach to overcome formulation difficulties towards dissolution/solubility. In this study SNEDDS  could be effectively developed and measured for its invitro and in vivo performance. In terms of droplet size, poly dispersibility index, dissolution and diffusion studies, S9 formulation showed promising result. Zeta potential of S9 formulation was -51.6 mV which indicates good stability and high degree of repulsion between adjacent, similarly charged globules in dispersion. Finally concluded that SNEDDS formation from captex-200, tween 80, PEG-200, Smix (surfactant co-surfactant ratio) (4:1) and Smix: oil ratio (1:9) is promising approach to improve the solubility, dissolution rate of drug.

connect us at saptanandi.1@gmail.com for the research paper more details 

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