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"Mechanistic Insights into Androgen Excess and Insulin Resistance in PCOS: Preclinical Evidence and Alternative Models for Translational Research"

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  Introduction:   Polycystic ovary syndrome (PCOS) is a complex endocrine, metabolic, and reproductive disorder affecting 6–20% of reproductive-age women worldwide. A hallmark of PCOS is androgen excess , which plays a crucial role in its pathophysiology, along with insulin resistance (IR). These factors contribute to reproductive dysfunction, metabolic abnormalities, and long-term health risks such as type 2 diabetes and cardiovascular diseases. Despite extensive research, the exact mechanisms underlying PCOS remain unclear, necessitating further exploration of androgen metabolism, insulin signaling, and alternative therapeutic strategies. Methods: This synthesizes findings from preclinical studies (in vivo and in vitro models) and computational approaches to elucidate the role of androgens and insulin resistance in PCOS. ·         Animal Models: Insights from rodent models of hyperandrogenism and insulin resistance (e.g., postnatal...
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The impact on pregnant people infected with the severe acute respiratory syndrome coronavirus 2 SARS-CoV-2) may be asymptomatic or symptomatic analysis by Saptadeep Nandi

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  The impact on pregnant people infected with the severe acute respiratory syndrome coronavirus 2 SARS-CoV-2) may be asymptomatic or symptomatic. Those who are symptomatic appear to be at increased risk for developing severe squeal of coronavirus disease 2019 (COVID-19) compared with nonpregnant reproductive-aged females. Need for the study:-  Diagnosis:- These physiologic changes make distinguishing pulmonary pathology difficult during pregnancy. This difficulty is heightened by the fact that COVID-19 infection has a wide array of presenting signs of symptoms. COVID-19 symptoms in pregnancy are similar to infections that occur in the general population with respect to presenting symptoms of cough (52%) and shortness of breath (30%). Pregnant women, however, were less likely to report symptoms of headache (41%), fever (34%), chills (38%), and diarrhea (14%) compared to the general population [5]. The other presenting symptoms, although less common, of COVID-19 infection, inclu...
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Nanoapproaches for Cystic Fibrosis – Design, Characterization and InVitro Evaluation by Saptadeep Nandi & team

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The following are the research works carried out by various researches Scholars that strongly support to carry out the present dissertation work.  Literature review : AnayatollahSalimi 1 , et al ., (2022) developed and characterized the Self-Emulsifying Drug Delivery System (SEDDS), to Improve the Oral bioavailability of poorly water soluble drug of Carvedilol. The percentage of drug release after 24 hours (R24) for Poloxamer and hydroxypropyl methylcellulose formulations were 61.24-70.61% and to 74.26-91.11%, individually. In permeation studies a significant and direct correlation existed between P4 and surfactant/co-surfactant ratio. The system (self-emulsifying drug delivery system) showed drug permeability through the rat intestine 2.76 times more, compared with the control. Hyma.P et al ., (2022) formulated and characterized the novel self-micro emulsifying drug delivery system of glimepiride to enhance the solubility and oral bioavailability of poorly water-soluble dru...
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M3DIMAKER FOR ORAL TAILORED-DOSE THERAPIES – A NEW EMERGING TECHNOLOGY FOR PERSONALIZED Review analysis by Saptadeep Nandi

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  M3DIMAKER: A Game Changer in Personalized Medicine Personalized medicine is the future of healthcare, where treatments are tailored to the unique needs of each patient. M3DIMAKER is a cutting-edge technology that revolutionizes the way oral tailored-dose therapies are developed and delivered. Advantages of M3DIMAKER: 1.       Precision Dosing: M3DIMAKER utilizes 3D printing technology to create precise doses of medication tailored to each patient's unique needs 2.       Improved Patient Outcomes: By delivering the right dose of medication to the right patient at the right time, M3DIMAKER has the potential to improve patient outcomes and reduce the risk of adverse reactions. 3.       Cost-effective: By reducing the need for multiple clinical trials and reducing the time it takes to bring personalized medicines to market, M3DIMAKER can help lower the cost of developing new treatments. 4.  ...
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Location: India
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